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Serum selenium levels and blood glutathione peroxidase activities in vitiligo
Author(s) -
Wayne D. Beazley,
David Gaze,
Angela Panske,
E Panzig,
Karin U. Schallreuter
Publication year - 1999
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1999.02980.x
Subject(s) - vitiligo , glutathione peroxidase , catalase , selenium , peroxidase , hydrogen peroxide , medicine , antioxidant , glutathione , endocrinology , chemistry , gpx3 , enzyme , biochemistry , immunology , organic chemistry
It has recently been shown that patients with vitiligo can accumulate epidermal hydrogen peroxide (H 2 O 2 ) in association with low catalase levels. This study examined serum selenium levels and blood glutathione peroxidase activities in 61 patients and controls. The results showed high serum selenium levels in 56% of the patients. As at least one isoform of glutathione peroxidase requires selenium for its activity, enzyme activities were also evaluated. The overall results were not significantly different compared with controls, but further age‐related analysis of the data indicated significantly lower activities in patients up to 46 years. As glutathione peroxidase can also efficiently degrade H 2 O 2 , the results of this study could indicate an additional impaired H 2 O 2 metabolism in vitiligo.