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Comèl–Netherton syndrome complicated by papillomatous skin lesions containing human papillomaviruses 51 and 52 and plane warts containing human papillomavirus 16
Author(s) -
Fölster-Holst,
Swensson,
Stockfleth,
Mönig,
Mrowietz,
Christophers
Publication year - 1999
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1999.02892.x
Subject(s) - epidermodysplasia verruciformis , human papillomavirus , dermatology , medicine , papillomaviridae , virology , pathology , virus , cancer , cervical cancer
We describe a 28‐year‐old woman with characteristic clinical signs of Comèl–Netherton syndrome (CNS) who showed numerous plane warts on her face and forearms and papillomatous skin tumours affecting her groins and genitoanal skin. Using human papillomavirus (HPV) type‐specific primers for cutaneous and mucosal HPV types we identified HPV 16‐specific sequences in plane warts and HPV 51‐ and HPV 52‐specific DNA in papillomatous skin from the patient's groins, suggesting a pathogenetic role (cofactor) for HPV in the development of verrucous skin lesions in patients with CNS. Whether the susceptibility to HPV infections is due to decreased cellular immunity or epidermal defence mechanisms remains to be seen.