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Analysis of c ‐ kit exon 11 and exon 17 of urticaria pigmentosa that occurred in monozygotic twin sisters
Author(s) -
Sato-Matsumura Kc,
Takehiko Matsumura,
Hidetaka Koizumi,
Hinako Sato,
Kazuo Nagashima,
Akira Ohkawara
Publication year - 1999
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1999.02890.x
Subject(s) - exon , pathogenesis , monozygotic twin , genetics , urticaria pigmentosa , mutation , genomic dna , biology , peripheral blood mononuclear cell , medicine , immunology , gene , in vitro
Genomic DNA extracted from peripheral blood mononuclear cells of monozygotic twin patients with urticaria pigmentosa was investigated for mutations of proto‐oncogene c‐ kit . Neither the patients nor their families had genomic mutations in exon 11 or exon 17 of c‐ kit . The patients did not have any systemic involvement or bone marrow abnormalities. There are indications that some genetic factors may participate in the pathogenesis of urticaria pigmentosa in monozygotic twins. In the present patients, factors other than genomic faults in exon 11 and exon 17 of c‐ kit may be responsible for the pathogenesis.