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Purpura of the ears: a distinctive vasculopathy with circulating autoantibodies complicating long‐term treatment with levamisole in children
Author(s) -
Rongioletti F,
Ghio L,
Ginevri F,
Bleidl D,
Rinaldi S,
Edefonti A,
Gambini C,
Rizzoni G,
Rebora A
Publication year - 1999
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1999.02833.x
Subject(s) - medicine , classics , library science , history , computer science
The cutaneous side‐effects of levamisole include non‐specific and lichenoid eruptions, fixed drug eruption and, very rarely, cutaneous vasculitis. We describe a distinctive clinical and histological vasculopathy with immunological abnormalities in children with paediatric nephrotic syndrome receiving long‐term levamisole treatment. Four boys and one girl were identified. Their average age was 10 years. Levamisole had been used for an average of 24 months. Purpura of the ears was the most common finding corresponding histologically to a vasculopathic reaction pattern ranging from a leucocytoclastic and thrombotic vasculitis to a vascular occlusive disease without true vasculitis but with associated antinuclear, antiphospholipid and anticytoplasmic antibodies. The eruption resolved in all patients 2–3 weeks after the discontinuation of levamisole, but serum autoantibodies persisted for 2–14 months.