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Bowen's disease showing spontaneous complete regression associated with apoptosis
Author(s) -
Chisiki M,
Kawada A,
Akiyama M,
Itoh Y,
Tajima S,
Ishibashi A,
Yudate F
Publication year - 1999
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1999.02831.x
Subject(s) - bowen's disease , lesion , apoptosis , dermis , regression , vascularity , fas receptor , disease , pathology , infiltration (hvac) , medicine , biology , programmed cell death , psychology , genetics , physics , basal cell , psychoanalysis , thermodynamics
Spontaneous regression is sometimes seen in malignant skin tumours. We report a 68‐year‐old woman whose Bowen's disease showed spontaneous complete regression. Prominent infiltration of T cells and increased vascularity were found in the upper dermis of the regressed lesion. Strong expression of Fas (APO‐1/CD95) antigen, an apoptosis‐related tumour necrosis factor receptor family protein, in the primary lesion and faint expression following regression suggest the involvement of Fas‐mediated apoptosis in the spontaneous complete regression of our patient's Bowen's disease.