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The induction by topical minoxidil of increased fenestration in the perifollicular capillary wall
Author(s) -
Shigeaki Sakita,
Masayori Kagoura,
Masahiko Toyoda,
Masaaki Morohashi
Publication year - 1999
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1999.02666.x
Subject(s) - minoxidil , fenestration , dorsum , medicine , vellus hair , dermatology , pathology , anatomy , surgery , scalp
We report the induction by topical minoxidil of increased fenestration in the perifollicular capillary wall. Male 30‐day‐old Wistar rats were divided into two groups, i.e. an experimental group which received 4% minoxidil solution topically on the dorsal skin, and a control group which received only vehicle solution topically. Using transmission electron microscopy, follicular and subepidermal capillaries and dermal fibres were compared between both groups. There were no obvious differences in subepidermal capillaries or dermal fibres between the two groups. However, topically applied minoxidil increased fenestration in follicular capillary walls around anagen hair bulbs.