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Pharmacology of adapalene
Author(s) -
Serge Michel,
A. Jomard,
Michel Démarchez
Publication year - 1998
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1998.1390s2003.x
Subject(s) - adapalene , retinoid , pharmacology , in vivo , acne , tazarotene , medicine , keratinocyte , in vitro , tretinoin , chemistry , dermatology , cancer research , biology , cellular differentiation , retinoic acid , biochemistry , microbiology and biotechnology , benzoyl peroxide , organic chemistry , polymerization , gene , polymer
Adapalene, a synthetic retinoid, is a new drug proposed for the treatment of acne patients. Studies on the in vitro and in vivo pharmacology of adapalene have shown that it is very active on cell and tissue proliferation and differentiation. Furthermore, adapalene has anti‐inflammatory potential as determined by its anti‐AP1 activity. Adapalene interacts selectively with the nuclear receptors RARβ and RARγ, and its activity on proliferation and differentiation can be blocked by a RARβ‐γ antagonist. Because RARβ is not expressed in human keratinocytes, the effect of adapalene on the major cell type of the epidermis is certainly mediated by its interaction with RARγ. The unique pharmacological properties of adapalene may explain why, when compared to tretinoin, it has an improved therapeutic ratio due to its better tolerance.