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Glomangiosarcoma of the hip: report of a highly aggressive tumour with widespread distant metastases
Author(s) -
Kazuo Watanabe,
Takashi Sugino,
Asami Saito,
Toru Kusakabe,
Takamasa Suzuki
Publication year - 1998
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1998.02574.x
Subject(s) - vimentin , pathology , desmin , leiomyosarcoma , eosinophilic , epithelioid cell , medicine , neoplasm , lung , biology , immunohistochemistry
Malignant glomus tumour is an extremely rare neoplasm, and only a few cases with local invasive or aggressive features have been described to date. We present a distinctive case of a malignant glomus tumour arising on the skin of the left hip of a 47‐year‐old woman. The primary tumour was small, with a maximum diameter of 1 cm, but 2 years after the tumour was excised, multiple lung and skin metastases appeared. Post‐mortem examination also revealed widespread metastases in almost all of the visceral organs. Histological examination showed that the primary tumour was composed of a sheet‐like proliferation of epithelioid round or short spindle cells surrounding small venules. In addition, there was a proliferation of long spindle cells with eosinophilic fibrillary cytoplasm, which mimicked a leiomyosarcoma. The tumour cells were intensely immunopositive for actin and vimentin but were negative for desmin. This is an exceptional case of malignant glomangiomyoma with widespread metastases, which represents a distinct variant of de novo glomangiosarcoma.