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Ichthyosiform erythroderma and cardiomyopathy: report of two cases and review of the literature
Author(s) -
Peter H. Hoeger,
Adwani Ss,
Whitehead Bf,
A.Y. Finlay,
J.I. Harper
Publication year - 1998
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1998.02565.x
Subject(s) - erythroderma , medicine , cardiomyopathy , failure to thrive , dermatology , pediatrics , dilated cardiomyopathy , heart transplantation , transplantation , heart failure , cardiology
We report two children with ichthyosiform erythroderma who at the ages of 9 weeks and 8 years, respectively, developed dilated cardiomyopathy, which was fatal in one and required heart transplantation in the other. A link between these conditions is considered likely, either as a primary genetic syndrome or secondary to micronutrient deficiency and/or infection. Owing to its insidious onset, cardiomyopathy may be overlooked, or symptoms attributed to the other conditions such as severe infections and failure to thrive that are common in these patients. We therefore recommend that children with congenital erythroderma are monitored closely, clinically and with echocardiography, for cardiomyopathy.