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1α,24‐Dihydroxyvitamin D 3 (tacalcitol) is effective against Hailey–Hailey disease both in vivo and in vitro
Author(s) -
Takehiko Aoki,
Hideki Hashimoto,
Shiro Koseki,
Yasukazu Hozumi,
Shigeo Kondô
Publication year - 1998
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1998.02522.x
Subject(s) - in vivo , lesion , medicine , biopsy , in vitro , pathology , dermatology , chemistry , biology , biochemistry , microbiology and biotechnology
We report a case of Hailey–Hailey disease (HHD) in which 1α,24‐dihydroxyvitamin D 3 (tacalcitol) was effective both clinically ( in vivo ) and in explant cultures ( in vitro ) of a skin lesion. The patient was a 65‐year‐old man with HHD lesions in the axillary and inguinal areas bilaterally. We applied ointment containing 1α,24‐dihydroxyvitamin D 3 (tacalcitol), an analogue of active vitamin D 3 , to the lesions and assessed its clinical effectiveness. The HHD lesions in both groins disappeared after treatment with the 1α,24‐dihydroxyvitamin D 3 ointment, and the remission has continued to the present. A punch biopsy specimen of the lesion that had remitted showed no acantholysis. In addition, dissociation of migrating keratinocytes was observed when biopsy specimens of the HHD skin lesion were cultured in medium without 1α,24‐dihydroxyvitamin D 3 , but inhibition of keratinocyte dissociation was observed in medium containing it. These results suggest the effectiveness of 1α,24‐dihydroxyvitamin D 3 against HHD both in vivo and in vitro .