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Sclerodermatous graft‐versus‐host disease after donor leucocyte infusion
Author(s) -
María JonesCaballero,
Jesús FernándezHerrera,
S. Córdoba-Guijarro,
Esteban DaudenTello,
Amaro GarcíaDíez
Publication year - 1998
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1998.02520.x
Subject(s) - medicine , graft versus host disease , bone marrow , immune system , immunology , disease , bone marrow transplant , bone marrow transplantation , graft vs host reaction , leukemia
Leucocyte infusion from the marrow donor is a new therapeutic option to avoid repeated bone marrow transplants in patients with recurrent leukaemia. The treatment is based on the fact that alloreactive donor immune cells may recognize and eliminate residual leukaemia cells. This phenomenon has been called graft‐versus‐leukaemia. We describe a patient who received donor leucocyte infusion for a relapsed chronic myeloid leukaemia after his second bone marrow transplant and developed sclerodermatous graft‐versus‐host disease.