Premium
Evidence for a second genetic locus in Carney complex
Author(s) -
Alan D. Irvine,
Steven R. Armstrong,
Bingham,
Hadden,
Austin Nevin,
H. Velocity Hughes
Publication year - 1998
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1998.02450.x
Subject(s) - carney complex , locus (genetics) , genetics , genetic linkage , genetic heterogeneity , multiple endocrine neoplasia , biology , medicine , phenotype , gene
Carney complex (MIM no. 160980) is an autosomal dominant condition of lentiginosis, cutaneous and cardiac myxomas and multiple endocrine neoplasia. A locus for Carney complex has recently been mapped to chromosome 2p16. We have studied two Northern Irish families with this disorder. Linkage analysis was performed on the families using five highly informative dinucleotide repeat markers covering this area. Negative logarithm of the odds scores were obtained for all markers at all recombination fractions. We conclude that Carney complex is genetically as well as clinically heterogeneous.