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Autoimmune progesterone dermatitis: treatment with oophorectomy
Author(s) -
J.M. Ródenas,
María Teresa Herranz,
Jesús Tercedor Sánchez
Publication year - 1998
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1998.02420.x
Subject(s) - medicine , triptorelin , mucocutaneous zone , oophorectomy , medroxyprogesterone acetate , dermatology , adverse effect , erythema , hormone , disease , surgery , hysterectomy , luteinizing hormone , gonadotropin releasing hormone
Autoimmune progesterone dermatitis is a rare manifestation of hypersensitivity to endogenous hormones with polymorphic clinical manifestations. We report a 28‐year‐old woman with a 5‐year history of mucocutaneous erythema multiforme occurring cyclically in the premenstrual period. Progesterone sensitivity was demonstrated by challenge test with medroxyprogesterone acetate. Treatments with oestrogens, tamoxifen and triptorelin had to be withdrawn because of intolerable adverse effects. Oophorectomy finally cured the disease.