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BAX protein is not expressed by basal cell carcinomas
Author(s) -
Rossen,
Karabulut Thorup,
Hou-Jensen,
Krag Jacobsen
Publication year - 1998
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1998.02412.x
Subject(s) - apoptosis , basal cell carcinoma , bax protein , bcl 2 family , gene , biology , gene family , bcl 2 associated x protein , gene expression , cancer research , protein family , microbiology and biotechnology , basal (medicine) , cell , programmed cell death , basal cell , protein expression , genetics , pathology , caspase 3 , medicine , endocrinology , insulin
BAX and related proteins encoded by the BCL2 gene family are involved in the regulation of apoptosis. BAX is an apoptosis‐promoting protein. The slow growth of basal cell carcinoma (BCC) has so far been explained by a high apoptotic activity. We investigated immunohistochemically 27 BCCs for expression of the apoptosis‐promoting BAX protein. BCC did not express detectable amounts of BAX immunohistochemically. The results indicate that apoptosis in BCC does not involve BAX protein. We propose that the apoptotic pathway in BCC is regulated by either less common members of the BCL2 gene family or bypasses the regulation of the BCL2 gene family.