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Long‐term outcome of severe chronic plaque psoriasis following treatment with high‐dose topical calcipotriol
Author(s) -
Bleiker To,
Bourke Jf,
Richard A. Mumford,
Hutchinson Pe
Publication year - 1998
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1998.02367.x
Subject(s) - calcipotriol , medicine , plaque psoriasis , dermatology , psoriasis , dermatologic agents , antibiotics , biology , microbiology and biotechnology
We have previously reported the effectiveness of high‐dose calcipotriol in extensive psoriasis. We now report the long‐term outcome in patients following this treatment. Twenty‐eight patients with severe psoriasis were treated as in‐patients with high‐dose topical calcipotriol for 2 weeks. There was a mean reduction in the psoriasis area and severity index of 65%. Sixty‐nine per cent were controlled for 3 months and 42% for 6 months. The relapse rate was comparable with that following Ingram's regimen, the in‐patient stay was shorter and the treatment more acceptable. Careful monitoring of calcium homeostasis is mandatory.