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Epidermodysplasia verruciformis‐like eruption complicating human immunodeficiency virus infection
Author(s) -
C Barzegar,
C. Paul,
Philippe Saïag,
P Cassenot,
Debabrata Bandyopadhyay,
Brigitte Autran,
Guy Gorochov,
Antoine Petit,
Louis Dubertret
Publication year - 1998
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1998.02328.x
Subject(s) - epidermodysplasia verruciformis , virology , virus , viral disease , human leukocyte antigen , immunology , papovavirus , cd8 , immunopathology , pityriasis , immunodeficiency , immune system , biology , medicine , antigen
Three human immunodeficiency virus (HIV)‐infected patients presented with disseminated pityriasis versicolor‐like skin lesions. Histological examination showed features characteristic of epidermodysplasia verruciformis (EV). Hybridization studies demonstrated the presence of human papillomavirus (HPV) type 5 (HPV5) DNA in two patients and HPV20 in one. A relative increase in CD8 +, CD57 + cells, which are known to inhibit cell‐mediated cytolysis, was observed in all patients. HLA‐DQB 0301 haplotype, which has been associated with EV, was detected in two patients. The findings suggest that infection with EV‐associated HPV types can complicate HIV infection. Both cellular immune defects and a hitherto unknown genetic background might explain the occurrence of EV in HIV‐infected patients.