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Pseudotumour of the tongue caused by herpes simplex virus type 2 in an HIV‐1 infected immunosuppressed patient
Author(s) -
R. Husak,
Beate Tebbe,
Sergij Goerdt,
Lutz-Uwe Wölfer,
H Zeichardt,
Marina StöfflerMeilicke,
C.E. Orfanos
Publication year - 1998
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1998.02327.x
Subject(s) - tongue , herpes simplex virus , medicine , biopsy , virus , virology , pathology , dermatology
An HIV‐1 infected immunosuppressed patient (CD4 + cell counts: 382 cells/μL; viral load 94,000 copies/mL) with recurrent perianal herpes simplex virus type 2 (HSV‐2) infections is described, showing an unusual exophytic tumour resembling a squamous cell carcinoma in the lateral part of the tongue. He also had persistent facial herpes infection, oral candidosis, oral hairy leukoplakia and lymphadenopathy. The presence of HSV‐2 was detected by polymerase chain reaction both in smears and in a tissue biopsy taken from the involved tongue area. Treatment with brivudin, a new oral virustatic drug, led to rapid regression of the tumour.