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Phagocytosis and oxidative burst by neutrophils in patients with recurrent furunculosis
Author(s) -
Zeynep Demirçay,
Emel Ekşioğlu,
Tülin Ergun,
T Akoğlu
Publication year - 1998
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1998.02274.x
Subject(s) - respiratory burst , phagocytosis , oxidative phosphorylation , flow cytometry , staphylococcus aureus , immunology , oxidative stress , neutrophile , medicine , microbiology and biotechnology , biology , inflammation , bacteria , biochemistry , genetics
Neutrophil phagocytosis of fluorescently labelled Staphylococcus aureus and oxidative burst by the neutrophils were assessed by flow cytometry in 22 patients with recurrent furunculosis and in 17 controls. Phagocytosis and oxidative burst were not found to be significantly different between the patients and controls. Low serum iron concentrations were demonstrated in six patients (27%). In these patients with hypoferraemia, oxidative burst was significantly lower than in the patients without hypoferraemia and in the controls. These data suggest that hypoferraemia may be an important predisposing factor in a subgroup of patients with recurrent furunculosis in impairing oxidative killing by neutrophils.