Premium
Aspirin‐sensitive urticaria: provocation with a leukotriene receptor antagonist
Author(s) -
Yoko Ohnishi-Inoue,
Kaoru Mitsuya,
Takeshi Horio
Publication year - 1998
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1998.02129.x
Subject(s) - provocation test , aspirin , medicine , antagonist , leukotriene receptor , leukotriene , receptor antagonist , pathogenesis , nasal provocation test , pharmacology , receptor , immunology , asthma , pathology , alternative medicine
The diagnosis of two patients with aspirin‐induced urticaria (AIU) was confirmed by oral provocation with aspirin, other non‐steroidal anti‐inflammatory drugs, and food additives. Low doses of a novel leukotriene (LT) receptor antagonist, ONO‐1078 (ONO, Japan) induced urticaria in these patients, while the same doses of ONO‐1078 did not provoke any eruptions in 10 normal healthy volunteers or five patients with aspirin‐unrelated chronic urticaria. This is the first report that a selective LTD4/LTE4 receptor antagonist that is effective as an antiasthmatic agent evoked urticaria in patients with AIU. Our observation suggests that the pathogenesis of AIU depends on the stimulation of LT receptors. The accumulation of results of anti‐LT therapy may provide clues to resolve the pathogenetic mechanisms of this disorder.