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Demodex folliculorum and topical treatment: acaricidal action evaluated by standardized skin surface biopsy
Author(s) -
F. Forton,
Seys,
Marchal,
Xianfang Song
Publication year - 1998
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1998.02125.x
Subject(s) - demodex , demodex folliculorum , dermatology , medicine , isotretinoin , metronidazole , benzyl benzoate , biopsy , antibiotics , rosacea , acne , mite , chemistry , biology , biochemistry , botany , organic chemistry
A standardized skin surface biopsy was performed in 34 patients suffering from skin diseases with high Demodex folliculorum density (Dd) > 5 D/cm 2 before, during and after topical treatment. The patients were randomized into six comparable groups to study six topical treatments: metronidazole 2%, permethrin 1%, sublimed sulphur 10%, lindane 1%, crotamiton 10% and benzyl benzoate (BB) 10%. Their acaricidal activity was measured according to three criteria: (i) for each treatment, decrease of Dd to under the normal threshold (≤ 5 D/cm 2 ); (ii) for each treatment, a significant decrease in Dd; and (iii) comparison of the relative difference in Dd between treatments. These three criteria converged to establish the acaricidal activity of BB on D. folliculorum ; the efficacy of crotamiton was demonstrated by the second criterion. An important irritating effect was observed with BB and sulphur.