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An indolent penile herpetic ulcer in a patient with previously undiagnosed human immunodeficiency virus infection
Author(s) -
Tayal,
Pattman,
Mclelland,
Sviland,
Snow
Publication year - 1998
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1998.02086.x
Subject(s) - medicine , herpes simplex virus , lesion , histopathology , virus , antibody , pathology , human immunodeficiency virus (hiv) , virology , biopsy , simplexvirus , viral disease , herpesviridae , immunology
We report a case of an atypical penile herpetic ulcer in a man with previously undiagnosed human immunodeficiency virus (HIV) infection. Swabs of the lesion were negative for herpes simplex virus (HSV) by culture and electron microscopy. However, histopathology of biopsy material showed characteristic herpetic multinucleate giant cells. Immunochemistry using polyclonal antibodies was positive for HSV1 and HSV2. The lesion completely resolved after treatment with aciclovir and the patient subsequently tested positively for HIV antibodies.