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Immediate‐type heat urticaria: report of a case and study of plasma histamine release
Author(s) -
Tsuyoshi Baba,
Kazuo Nomura,
Kenichi Hanada,
Isao Hashimoto
Publication year - 1998
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1998.02084.x
Subject(s) - histamine , desensitization (medicine) , medicine , provocation test , plasma levels , skin test , dermatology , anesthesia , pathology , tuberculosis , alternative medicine , receptor
We report a 68‐year‐old man who had immediate‐type heat urticaria with systemic symptoms. Immersing his hand in water at 42 °C (heat challenge test) produced an urticarial response, with an increase in the plasma histamine level from 0.26 to 7.64 ng/mL. Administration of oral antihistamines alone did not suppress either the urticarial response or the increase in plasma histamine. However, a combination of antihistamines and desensitization improved the skin lesions and reduced the plasma histamine level. The heat challenge test subsequently provoked a negative response and there was no increase in plasma histamine level 3 months after starting the combination therapy. These results indicate that the histamine level reflected the result of the heat challenge test and the amelioration of the skin eruption.