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Assignment of three Chinese xeroderma pigmentosum patients to complementation group C and one to group E
Author(s) -
Han Zb,
Ryujiro Hara,
Hitoshi Ayaki,
Wang Jh,
Lingyun Sun,
Yong You,
Zhang Yp,
Qiang Kx,
Mituo Ikenaga
Publication year - 1998
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1998.02039.x
Subject(s) - xeroderma pigmentosum , complementation , group a , group (periodic table) , medicine , genetics , dermatology , biology , chemistry , gene , phenotype , dna repair , organic chemistry
Four Chinese patients with xeroderma pigmentosum (XP), who had different degrees of skin symptoms, were tested for their genetic complementation groups. Skin fibroblasts obtained from the patients were used for complementation analysis done by a cell‐fusion technique. Three of the patients belonged to group C and one, who had the mildest cutaneous manifestations, to group E. This is the first report of a group E XP patient in China. Our present findings together with previous reports suggest that group C XP is more common in China, similar to the distribution among Caucasian XP patients but markedly different from the Japanese distribution.