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Expression of transglutaminase 1 in human hair follicles, sebaceous glands and sweat glands
Author(s) -
Kozo Yoneda,
Masashi Akiyama,
Kazumasa Morita,
Hiroshi Shimizu,
Sadao Imamura,
Kim Sy
Publication year - 1998
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1998.02024.x
Subject(s) - immunoelectron microscopy , outer root sheath , sweat gland , biology , sweat , tissue transglutaminase , anatomy , inner root sheath , infundibulum , hair follicle , cuticle (hair) , exocrine gland , keratin , in situ hybridization , immunofluorescence , immunohistochemistry , microbiology and biotechnology , enzyme , endocrinology , gene expression , biochemistry , secretion , gene , antibody , paleontology , immunology
To explore the function of the enzyme transglutaminase 1 (TGase 1), its distribution was analysed by immunofluorescence microscopy, postembedding immunoelectron microscopy and in situ hybridization. TGase 1 was expressed in the outer root sheath (ORS) cells in the distal portion of the isthmus and infundibulum of human hair follicles. In the level of the proximal and middle portion of the isthmus, TGase 1 was observed in the keratinized area of the inner root sheath (IRS) and ORS cells. In the bulbar and suprabulbar portions, TGase 1 was present in the ORS and IRS cells. The cortex and medulla cells in these regions also contained TGase 1. A high level of fluorescence was observed at the cuticle of the cortex. Sebaceous and sweat gland cells contained abundant TGase 1. Possible functions of TGase 1 in these epidermal appendages are discussed.