Premium
Expression of adhesion molecules in pagetoid reticulosis (Woringer‐Kolopp disease)
Author(s) -
DRILLENBURG P.,
BRONKHORST C.M.,
WAL A.C.,
NOORDUYN L.A.,
HOEKZEMA R.,
PALS S.T.
Publication year - 1997
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1997.d01-1247.x
Subject(s) - lymphocyte homing receptor , cell adhesion molecule , homing (biology) , pagetoid , neural cell adhesion molecule , biology , pathology , cell adhesion , lymphoma , microbiology and biotechnology , immunology , immunohistochemistry , cell , medicine , genetics , ecology
Summary Cell adhesion molecules play a critical role in lytnphocyte migration and homing. They convey tissue‐specific homing properties to lymphocyte subsets and regulate the positioning of these subsets in the body. In a patient with pagetoid reticulosis. a rare form of cutaneous T‐cell lymphoma characterized by extreme epitheliotropism. we examined the expression of adhesion molecules. The neoplastic T lymphocytes showed a strong expression of cutaneous lymphocyte antigen, a skinhoming receptor which interacts with E‐selectin on skin endothelium. α E β 7 , an adhesion molecule interacting with E‐cadherin on epithelial cells, was also expressed on tumour cells. These findings suggest that adhesion molecules are responsible for the unque growth pattern in pagetoid reticulosis. and for the clinical behaviour of the disorder.