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A novel human papillomavirus identified in epidermodysplasia verruciformis
Author(s) -
HARRiS A.J.,
PURDIE K.,
LEIGH I.M.,
PROBY C.,
BURGE S.
Publication year - 1997
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1997.d01-1240.x
Subject(s) - epidermodysplasia verruciformis , human papillomavirus , dermatology , medicine , virology
Summary Epidermodysplasia verruciformis (EV) is a rare inherited condition in which there is widespread infection with human papillomavirus (HPV). Patients have a high risk of developing squamous cell carcinoma and Bowen's disease on sun‐exposed sites. We describe a Jatnaican man with the typical clinical and histopathological features of EV. HPV 8·24 and a subtype of HPV 38, along with a novel HPV sequence most closely related to HPV 9 have been detected in his skin lesions. Although skin tumours are rare In black patients with EV and he has lived in a temperate climate most of his life, several of the lesions showed bowenoid atypia and he is at risk of developing invasive cutaneous malignancies.