Premium
Expression of endothelial nitric oxide synthase in human eccrine clear cells
Author(s) -
SIIIMIZU Y.,
SAKAI M.,
UMEMURA Y.,
UEDA H.
Publication year - 1997
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1997.d01-1237.x
Subject(s) - nitric oxide synthase , enos , nitric oxide , endothelial nos , endocrinology , medicine , myoepithelial cell , biology , eccrine sweat gland , sweat gland , chemistry , immunohistochemistry , sweat
Summary Nitric oxide is generated from L‐arginine by nitric oxide synthase (NOS), which has at least three isoJorms: endothelial‐type NOS (eNOS) and brain‐type NOS (bNOS) are constitutive enzymes, and inducible‐type NOS (iNOS) is expressed after stimulation. Studies by the avidin‐biotin immunocomplex method, revealed eNOS immunoreactivity exclusively in the human eccrine clear cells. No eNOS immunoreactivity was observed in the eccrine dark cells or myoepithelial cells. No staining of iNOS or bNOS was observed in the eccrine yland. These findings indicate that NO pUiys a physiological part in the production and/or excretion of sweat in the human skin eccritie gland.