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Pemphigoid nodularis: a report of three cases and review of the literature
Author(s) -
CLIFF S.,
HOLDEN C.A.
Publication year - 1997
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1997.d01-1209.x
Subject(s) - medicine , prurigo nodularis , direct fluorescent antibody , pemphigoid , dermatology , basement membrane , bullous pemphigoid , immunofluorescence , pathology , antibody , indirect immunofluorescence , immunology
Summary Many variants of bullous pemphigoid have been reported, some of which are clinically very atypical. One of the rarest variants is pemphigoid nodularis. We report three patients with this distinct entity. In all three cases patients initially presented with prurigo‐like lesions and in one case nodular lesions preceded the onset of blistering by many months. Direct immunofluorescence was positive in all cases, with linear basement membrane zone deposition of IgG and C3. Circulating IgG antibasement membrane antibody was detected in two cases. and in these two patients on salt‐split immunofluorescence the antibodies bound to the roof of the bullae.