Premium
Systemic lupus erythematosus complicating complement type 2 deficiency: successful treatment with fresh frozen plasma
Author(s) -
HUDSONPEACOCK M.J.,
JOSEPH S.A.,
COX J.,
MUNRO C.S.,
SIMPSON N.B.
Publication year - 1997
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1997.d01-1207.x
Subject(s) - medicine , fresh frozen plasma , depression (economics) , systemic lupus erythematosus , lupus erythematosus , disease , dermatology , immunology , antibody , platelet , economics , macroeconomics
Summary We report a man who presented in 1981 at the age of 30 with cutaneous lupus erythematosus (LE), which was resistant to a range of treatments over the subsequent 11 years. In 1991 he suffered fits, dysphasia and agitated depression, and in 1992 a severe septicaemic illness. Systemic LE was diagnosed, and investigation showed homozygous complement type 2 deficiency (C2d). Over a period of 30 months he has received 6 weekly fresh frozen plasma. Since starting this treatment his cutaneous disease has resolved and his depression, verbal fluency and psychomotor scores improved. We have not observed any adverse effects to this treatment and suggest it should be considered in similar patients.