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A typical case of pemphigoid gestationis with a unique pattern of intercellular immunofluorescence
Author(s) -
JONES S.A.VAUGHAN,
BHOGAL B.S.,
BLACK M.M.,
CLEMENT M.,
HASHIMOTO T.,
NISHIKAWA T.
Publication year - 1997
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1997.d01-1179.x
Subject(s) - immunofluorescence , bullous pemphigoid , medicine , pemphigoid , direct fluorescent antibody , pathology , antibody , third trimester , dermatology , abdomen , pregnancy , immunology , fetus , biology , surgery , genetics
Summary Pemphigoid gestationis is an autoimmune bullous disorder affecting pregnant women which typically presents in the second and third trimester of pregnancy with an itchy bullous eruption on the abdomen and limbs. The diagnosis is confirmed by the presence of complement‐binding IgG antibasement membrane zone (BMZ) antibodies, which bind to the roof of salt‐split skin. We describe a case of clinically typical pemphigoid gestationis with the combination of intercellular IgG and BMZ IgG and C3 staining on immunofluorescence, a pattern which is unique for this condition.