Premium
Mosaic expression of uncein and 180‐kDa bullous pemphigoid antigen in generalized atrophic benign epidermolysis bullosa
Author(s) -
MATSUMURA Y.,
HORIGUCHI Y.,
TODA K.,
FUJII H.,
KOREEDA S.,
TACHIBANA T.,
OHTA K.,
OKAMOTO H.,
IMAMURA S.
Publication year - 1997
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1997.6701619.x
Subject(s) - immunoelectron microscopy , bullous pemphigoid , pathology , epidermolysis bullosa , immunofluorescence , basement membrane , lamina lucida , laminin , staining , immunohistochemistry , direct fluorescent antibody , antigen , medicine , epidermolysis bullosa acquisita , cicatricial pemphigoid , anchoring fibrils , pemphigoid , antibody , biology , immunology , extracellular matrix , microbiology and biotechnology , ultrastructure , basal lamina
Summary Immunofluorescence microscopy of epidermodermal junction components in serial cryosections from the perilesional skin of a patient with generalized atrophic benign epidermolysis bullosa (GABEB) showed broken line‐like staining of both BPAG2 (180‐kDa bullous pemphigoid antigen) and uncein (antigen of 19‐DEJ‐l monoclonal antibody), whereas integrin α6 and laminin 5 were continuously expressed along the basement membrane zone. Immunoelectron microscopy revealed a mosaic distribution of the BPAG2/uncein positive and negative cells. BPAG2, a candidate protein of GABEB, probably has a close connection with uncein, an anchoring filament component.