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Epidermal naevi associated with trichilemmal cysts and chromosomal mosaicism
Author(s) -
ZAMORA M.E. IGLESIAS,
VÁZQUEZDOVAL F.J.
Publication year - 1997
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1997.19612035.x
Subject(s) - hair disease , dermatology , biology , medicine
Summary We present the case of a 29‐year‐old woman who has had a widespread epidermal naevus since birth, located on the left side of her body, upon which multiple trichilemmal cysts developed several years later. The karyotype of peripheral blood lymphocytes revealed chromosomal mosaicism 46, XX, t (1:9) (p36:q34). The possible pathogenic mechanisms include paracrinopathy, germinal or somatic mutation in the multipotential embryo cells, or a combination of the two.