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Squamous cell carcinoma, malignant melanoma and malignant fibrous histiocytoma arising in burn scars
Author(s) -
ALCONCHEL M.D.,
OLIVARES C.,
ALVAREZ R.
Publication year - 1997
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1997.19552041.x
Subject(s) - medicine , melanoma , malignant transformation , scars , pathology , immunohistochemistry , basal cell , dermatology , skin cancer , cancer , cancer research
Summary The most common cancer arising from an old burn scar is squamous cell carcinoma, while malignant melanoma is rare. There are only four reports in the literature on the combination of the more common tumour with a malignant melanoma and only two cases of malignant fibrous histiocytoma alone. This paper reports the first occurrence of the combination of all three types of cancer in burn scars of the same patient. The factors that promote malignant transformation, such as immunological factors and karyotype, are discussed. We also performed an immunohistochemical study using anti‐p53 antibodies.