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Psoriasis vulgaris coexistent with epidermolysis bullosa acquisita
Author(s) -
ENDO Y.,
TAMURA A.,
ISHIKAWA O.,
MIYACHI Y.,
HASHIMOTO T.
Publication year - 1997
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1997.19532043.x
Subject(s) - epidermolysis bullosa acquisita , pemphigus vulgaris , bullous pemphigoid , medicine , dermatology , psoriasis , pemphigoid , autoantibody , dermatitis herpetiformis , autoimmune disease , basement membrane , epidermolysis bullosa , pathology , immunology , antibody , disease
Summary Autoimmune bullous diseases, such as bullous pemphigoid or pemphigus vulgaris. occasionally develop in psoriatic patients. In addition, a novel subepidermal bullous disease with autoantibodies against a lower lamina lucida antigen of 200kDa has recently been reported in association with psoriasis. We describe here a patient with psoriasis vulgaris who developed epidermolysis bullosa acquisita (EBA). Direct immunofluorescence revealed linear deposition of IgCl and C3 at the basement membrane zone. The patient's serum bound to the dermal side of salt‐split normal human skin. However, immnumohlol analysis demonstrated that the patient's serum reacted with an EBA antigen of 290 kDa. EBA should be included in the list of autoimmune diseases associated with psoriasis vulgaris.