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Anti‐epiligrin (laminin 5) cicatricial pemphigoid and lung carcinoma: coincidence or association?
Author(s) -
GIBSON G.E.,
DAOUD M.S.,
PITTELKOW M.R.
Publication year - 1997
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1997.19522044.x
Subject(s) - cicatricial pemphigoid , autoantibody , medicine , laminin , carcinoma , pathology , antibody , lung , epitope , dermatology , pemphigoid , immunology , bullous pemphigoid , biology , extracellular matrix , microbiology and biotechnology
Summary Anti‐epiligrin cicatricial pemphigoid (CP) is a rare subset of CP in which patients have IgG autoantibodies directed against the dermal side of skin split by 1 mol/L NaCl. The antibodies react against epitopes in the lowermost portions of the lamina lucida. and immunoprecipitate epiligrin (laminin 5) in human keratinocyte extracts. We report a patient with this uncommon form of CP, who. following an 8‐year period of well‐controlled disease, experienced a severe flare in symptoms coincident with development of lung carcinoma. This raises the possibility of an association, in this case, between anti‐epiligrin CP and lung carcinoma.