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A randomized double‐blind comparative study of terbinafine for 1, 2 and 4 weeks in tinea capitis
Author(s) -
HAROON T.S.,
HUSSAIN I.,
AMAN S.,
JAHANGIR M.,
KAZMI A.H.,
SAMI A.R.,
NAGI A.H.,
ALVI K.H.,
IQBAL N.,
KHAN K.A.,
AZIZ R.
Publication year - 1996
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1996.d01-938.x
Subject(s) - terbinafine , tinea capitis , medicine , dermatology , tolerability , microsporum canis , dermatophyte , double blind , adverse effect , randomized controlled trial , placebo , itraconazole , antifungal , pathology , alternative medicine
Summary We report a randomized, double‐blind study, comparing the relative efficacy and tolerability of oral terbinafine, given for 1, 2 or 4 weeks, in tinea capitis. Of 161 evaluable patients, 53 were treated with terbinafine for 1 week, 51 for 2 weeks and 57 for 4 weeks. Isolated pathogens included Trichophyton violaceum (71.5%), T. tonsurans (14.9%), T. verrucosum (4.3%), Microsporum audouinii (4.3%), M. canis (2.5%), T. schoenleinii (1.9%) and T. mentagrophytes (0.6%). The final evaluation, at 12 weeks, showed cure rates of 73.6, 80.4 and 85.9%, in the respective groups. The adverse effects noted, were not drug related. In our opinion, terbinafine given for 1, 2 or 4 weeks, is equally effective for most cases of tinea capitis.