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Keratinocytes express dipeptidyl‐peptidase IV (CD26) in benign and malignant skin diseases
Author(s) -
NOVELLI M.,
SAVOLA P.,
FIERRO M.T.,
VRRRONE A.,
QUAGLINO P.,
BERNENGO M.G.
Publication year - 1996
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1996.d01-900.x
Subject(s) - psoriasis , keratinocyte , epidermis (zoology) , immunohistochemistry , pathology , dipeptidyl peptidase , pathological , staining , basal (medicine) , medicine , biology , dermatology , cell culture , enzyme , anatomy , biochemistry , genetics , insulin
Summary CD26 expression on keratinocytes, in both normal and pathological skin, was investigated using Immunohistochemlcal techniques. A sporadic focal CD26 positivity was found in normal skin, whereas increased expression of CD26 was observed both in cutaneous T‐cell lymphomas and in inflammatory skin diseases, e.g. psoriasis, lichen planus and spongiotic dermatitis, in the basal and spinous layers, CD26 keratinocyte staining was not specific for a single disease, but seems to be associated with the presence of a reactive or neoplastic infiltrate in the epidermis. We propose that the CD26molecule may function as a keratinocyte activation antigen.