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Photo‐induced toxic epidermal necrolysis caused by clobazam
Author(s) -
REDONDO P.,
VICENTE J.,
ESPANA A.,
SUBIRA M.L.,
FELIPE I.,
QUINTANILLA E.
Publication year - 1996
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1996.d01-1111.x
Subject(s) - clobazam , toxic epidermal necrolysis , dermatology , medicine , psychiatry , epilepsy
SUMMARY Toxic epidermal necrolysis (TEN) is a life‐threatening disease, the pathogenesis of which remains largely unknown. We describe a 23‐year‐old woman under treatment with clobazam who developed lesions of TEN In light‐exposed areas. Patch and photopatch tests with clobazam were negative. The cellular phenotype and cytokines were studied in blister fluid. The cellular infiltrate was composed mainly of T lymphocytes with a predominant cyloloxic phenotype. Tbere was an increase in the level of tumour necrosis factor (TNF)‐α in blister fluid compared with the control (a patient with bullous pemphigoid).