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Immunoglobulin A (IgA) deposits in lesional skin of a patient with blepharochalasis
Author(s) -
GRASSEGGER A.,
ROMANI N.,
FRITSCH P.,
SMOLLE J.,
HINTNER H.
Publication year - 1996
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1996.d01-1081.x
Subject(s) - reticular dermis , immunoelectron microscopy , cutis laxa , pathology , medicine , dermis , reticular connective tissue , dermoepidermal junction , papillary dermis , immunofluorescence , dermatology , antibody , immunohistochemistry , immunology
Summary We describe a 21‐year‐old male patient with blepharochalasis, a form of localized acquired cutis laxa. He had a 13‐year history of recurrent swelling attacks of the eyelids of unknown origin leading to periocular localized cutis laxa. Histology of lesional skin confirmed almost complete loss of elastic fibres in the reticular and papillary dermis. Immunofluorescence and immunoelectron microscopy studies showed abundant immunoglobulin A (IgA) deposits around the remaining elastic fibres. Control skin of the forearm was negative. These findings support the hypothesis that immunopathogenetic mechanisms may contribute to the elastolytic process of blepharochalasis.