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Immunohistochemical and virological study of skin in the papular‐purpuric gloves and socks syndrome
Author(s) -
ARACTINGI S.,
BAKHOS D.,
FLAGEUL B.,
VÉROLA O.,
BRUNET M.,
DUBERTRET L.,
MORINET F.
Publication year - 1996
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1996.d01-1048.x
Subject(s) - parvovirus , medicine , immunohistochemistry , pathology , skin biopsy , epidermis (zoology) , pathogenesis , staining , antibody , virus , dermatology , immunology , biopsy , anatomy
Summary The pathogenesis of viral exanthems remains unclear. We have undertaken an immunohistochemical study of lesional skin biopsies in patients with the papular‐purpuric gloves and socks syndrome (PPGSS) secondary to parvovirus B19 infection. Intracytoplasmic staining of the dermal endothelial cells, keratinocytes, and sweat glands was shown with an antibody to parvovirus B19. There were perivascular dermal infiltrates with T cells, sometimes with exocytosis. By polymerase chain reaction, virus DNA was detected in all skin biopsies and in one serum sample. The cutaneous manifestations of parvovirus infection seem secondary to infection of the endothelium and epidermis.