Premium
Autoantibodies to bullous pemphigoid and epidermolysis bullosa acquisita antigens in an infant
Author(s) -
KAWACHI Y.,
IKEGAMI M.,
HASHIMOTO T.,
MATSUMURA K.,
TANAKA T.,
OTSUKA F.
Publication year - 1996
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1996.d01-1018.x
Subject(s) - epidermolysis bullosa acquisita , bullous pemphigoid , autoantibody , medicine , antigen , epidermolysis bullosa , cicatricial pemphigoid , pemphigoid , dermatology , antibody , immunology
Summary We describe a 1‐year‐old boy with multiple tense blisters on the skin, who showed circulating autoantibodies directed to both bullous pemphigoid and epidermolysis bullosa acquisita antigens. The patient's serum IgG antibodies bound to the 290‐kDa epidermolysis bullosa acquisita antigen with immunoblot analysis of human dermal extracts. Immunoblot analysis also demonstrated that the patient's serum autoantibodies were reactive with recombinant NC16a domain of the 180‐kDa bullous pemphigoid antigen. This study confirmed the presence of circulating autoantibodies directed to both bullous pemphigoid antigen and epidermolysis bullosa acquisita antigen.