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An immunohistochemical study of the dermal infiltrate and epidermal staining for interleukin 1 in 12 cases of Sweet's syndrome
Author(s) -
BOURKE J. F.,
JONES J.L.,
GRAHAMBROWN R. A. C.
Publication year - 1996
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1996.81843.x
Subject(s) - sweet's syndrome , dermis , immunohistochemistry , staining , pathophysiology , pathology , histiocyte , medicine , interleukin , sweet syndrome , dermatology , immunology , cytokine
Summary Interleukin 1 (IL‐1) has been proposed as a possible mediator in Sweet's syndrome. We examined all cases of Sweet's syndrome (M = 12) presenting to the department over a 10‐year period, from 1982 to 1992, for the presence IL‐l and also assessed the nature of the dermal inflammatory infiltrate in those cases. Staining for IL‐1α and TL‐1β was stronger in control tissues than in Sweet's syndrome. This may possibly be explained by the release of IL‐1α and IL‐1β into the dermis in Sweet's syndrome. Contrary to recent reports, we found that neutrophils predominated in all cases examined, although histiocytes were present in increased numbers indicating their possible role in the pathophysiology of Sweet's syndrome.