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Dermatological presentation of disease associated with antineutrophil cytoplasmic antibodies: a report of two contrasting cases and a review of the literature
Author(s) -
IRVINE A.D.,
BRUCE I.N.,
WALSH M.,
BURROWS D.,
HANDLEY J.
Publication year - 1996
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1996.129864.x
Subject(s) - medicine , pyoderma gangrenosum , anti neutrophil cytoplasmic antibody , vasculitis , dermatology , pathology , glomerulonephritis , systemic disease , pathological , disease , granulomatosis with polyangiitis , pyoderma , necrotizing vasculitis , kidney
Summary Antineutrophil cytoplasmic antibody (ANCA)‐associated disease (AAD) constitutes a pathological disease spectrum of a necrotizing vasculitis of small‐ and medium‐sized vessels, extravascular granuloma formation. and necrotizing and crescentic glomerulonephritis. and also a clinical disease continuum which ranges from renal‐limited disease to a widespread systemic vasculitis. including Wegener's granulomatosis and microscopic polyangiitis. In the latter, circulating ANCA are an aid to diagnosis and also may play a pathogenic part. Two contrasting patients with AAD are described. both of whom presented primary with dermatological features. These included a cutaneous purpuric vasculitis. orogenital ulceration. infarction of the fingertip, and pyoderma gangrenosum‐like ulceration. These cases will familiarize dermatologists with both the concept and dermatological features of AAD.