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Specificity of antinuclear antibodies in scleroderma‐like chronic graft‐versus‐host disease: clinical correlation and histocompatibility locus antigen association
Author(s) -
BELL S.A.,
FAUST H.,
MITTERMÜLLER J.,
KOLB H.J.,
MEURER M.
Publication year - 1996
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1996.116851.x
Subject(s) - scleroderma (fungus) , medicine , anti nuclear antibody , immunology , graft versus host disease , autoantibody , serology , human leukocyte antigen , histocompatibility , antibody , connective tissue disease , autoimmune disease , crest syndrome , antigen , disease , pathology , inoculation
Summary Chronic graft‐versus‐host disease after bone marrow transplantation presents, in a few cases, as mild to severe scleroderma‐like changes. Patients with chronic graft‐versus‐host disease with and without sclerodermatous skin changes were analysed for antinuclear autoantibodies (ANA) and antinucleolar autoantibodies (ANoA) and the results correlated with disease symptoms and histocompatibility locus antigen (HLA) pattern. Nineteen patients with chronic graft‐versus‐host disease and scleroderma‐like skin changes. 18 with chronic graft‐versus‐host diseae without scleroderma. and 17 controls on immunosuppressive treatment were screened for ANA and ANoA using enzyme‐linked immunosorbent assay, immunodiffusion and immunoblot techniques. Four patients with severe scleroderma had antibodies to topoisomerase I. two had antibodies against PM‐Scl. both characteristic serological findings in idiopathic systemic scleroderma. One patient had La/SSB antibodies and, in three cases, antibodies to the nucleolar antigen C23 (nucleolin) could be identified. A possible correlation between antinucleolin antibodies and disease activity was observed. HLA‐Al. ‐B1. and ‐B2 were found significantly more often in patients with scleroderma‐like symptoms in comparison to patients without scleroderma‐like symptoms. Chronic graft‐versus‐host disease with seleroderma‐like manifestations can be associated with the occurrence of ANA specific for idiopathic scleroderma. The development of seleroderma after bone marrow transplantation might have a HLA‐linked genetic background.