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Nitrate tolerance and the links with endothelial dysfunction and oxidative stress
Author(s) -
Fayers Katherine E.,
Cummings Michael H.,
Shaw Kenneth M.,
Laight David W.
Publication year - 2003
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1046/j.1365-2125.2003.01946.x
Subject(s) - nitric oxide , oxidative stress , endothelial dysfunction , vasodilation , function (biology) , nitrate , reactive oxygen species , endothelium , medicine , chemistry , pharmacology , biology , microbiology and biotechnology , biochemistry , organic chemistry
Identification of nitric oxide as the molecule responsible for endothelial dependant vasodilatation has led to an explosion of interest in endothelial function. Oxidative stress has been identified as an important factor in the development of tolerance to organic nitrates. This review examines the evidence supporting this recently developed theory and how mechanisms of nitrate tolerance may link with the wider picture of primary nitric oxide resistance.