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Add‐on therapy with montelukast or formoterol in patients with the glycine‐16 β 2 ‐receptor genotype
Author(s) -
Sims Erika J.,
Jackson Catherine M.,
Lipworth Brian J.
Publication year - 2003
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1046/j.1365-2125.2003.01899.x
Subject(s) - formoterol , montelukast , medicine , placebo , crossover study , formoterol fumarate , endocrinology , spirometry , corticosteroid , genotype , gastroenterology , asthma , budesonide , biology , biochemistry , alternative medicine , pathology , gene
Aims We assessed whether montelukast or formoterol provides additive effects to asthmatics not controlled on inhaled corticosteroids, by studying patients who were considered to be genetically susceptible to β 2 ‐receptor down regulation and subsensitivity, and who expressed the homozygous glycine‐16 β 2 ‐receptor genotype. Methods Fifteen corticosteroid‐treated, mild to moderate persistent asthmatics received montelukast 10 mg once daily or formoterol 9 µg twice daily for 2 weeks, separated by a 2‐week placebo run‐in and washout, in a double‐blind, double‐dummy, randomized crossover design. Bronchoprotection against adenosine monophosphate (AMP) challenge (primary endpoint), spirometry and blood eosinophils were measured at trough after placebo, first and last doses. Results For AMP PC 20 vs placebo, there were sustained significant ( P < 0.05) doubling dilution improvements following first (1.1; 95% CI 0.4, 1.9) and last (1.0; 95% CI 0.3, 1.8) doses of montelukast, and following first (1.3; 95% CI 0.1, 2.6) but not last (0.3; 95% CI −0.9, 1.6) doses of formoterol. Blood eosinophils (× 10 6 l −1 ) were significantly ( P < 0.05) suppressed after the last dose of montelukast (−71; 95% CI −3, −140) compared with placebo, while formoterol exhibited a nonsignificant rise (20; 95% CI −92, 132). Neither treatment significantly improved FEV 1 , FEF 25‐75 or PEF after 2 weeks. Conclusions In genetically susceptible patients with the homozygous glycine‐16 genotype, montelukast, but not formoterol, conferred sustained anti‐inflammatory properties in addition to inhaled corticosteroid, which were dissociated from changes in lung function after 2 weeks. Thus, assessing lung function may miss potentially beneficial anti‐inflammatory effects of montelukast when used as add‐on therapy.