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Allele and genotype frequency of CYP2C19 in a Tamilian population
Author(s) -
Adithan C.,
Gerard N.,
Vasu S.,
Rosemary J.,
Shashindran C. H.,
Krishnamoorthy R.
Publication year - 2003
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1046/j.1365-2125.2003.01883.x
Subject(s) - cyp2c19 , genotype , allele , allele frequency , confidence interval , population , biology , genetics , medicine , gene , environmental health
Aims To investigate the frequencies of CYP2C19 * 1 , CYP2C19 * 2 and CYP2C19*3 alleles and CYP2C19 genotypes in a Tamilian population. Methods The study was conducted in 112 unrelated healthy human volunteers. DNA was extracted from leucocytes and analyzed by the PCR‐RFLP protocol. The PCR product was digested with restriction enzymes ( Sma I and BamH 1) and then separated electrophoretically using polyacrylamide gel. Results The frequencies of the CYP2C19 * 1 , *2 and *3 alleles were 0.598 [95% confidence interval (CI) 0.507, 0.689], 0.379 (95% CI, 0.350,0.407) and 0.022 (95% CI −0.005, 0.049), respectively. The distribution of CYP2C19 * 1/*1 , *1/*2, *1/*3, *2/*2 and *2/*3 genotypes were 0.295 (95% CI, 0.210, 0.379), 0.580 (95% CI, 0.488, 0.671), 0.027 (95% CI −0.003, 0.057), 0.080 (95% CI 0.030, 0.130) and 0.018 (95% CI −0.006, 0.042), respectively. Conclusions The distribution of CYP2C19 * 1/*1 in the Tamilian population is lower than that in Caucasians, Africans and the North Indian population. The CYP2C19 * 1/*2 is significantly higher in Tamilians when compared with other populations. The CYP2C19 * 1/*3 allele, which was not reported in the North Indian and Caucasian populations has been identified in 2.7% of the Tamilian population.