Premium
Arylamine N ‐acetyltransferase‐2 genotypes in the Thai population
Author(s) -
Kukongviriyapan Veerapol,
Prawan Auemduan,
Tassaneyakul Wichittra,
Aiemsaard Jareerat,
Warasiha Benjamart
Publication year - 2003
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1046/j.1365-2125.2003.01766.x
Subject(s) - thais , genotype , arylamine n acetyltransferase , allele , biology , genetics , polymerase chain reaction , polymorphism (computer science) , allele frequency , population , medicine , gene , demography , environmental health , sociology
Aims To determine the frequencies of the major arylamine‐ N ‐acetyltransferase‐2 ( NAT2 ) alleles in the Thai population.Methods DNA samples from 235 Thai individuals were analysed by polymerase chain reaction with restriction fragment length polymorphism assays.Results The frequency distribution of major NAT2 alleles, including NAT2 * 4 , NAT2 * 5, NAT2 * 6 and NAT2 * 7 were 0.381 (95% CI 0.337, 0.426), 0.038 (0.023, 0.060), 0.326 (0.283, 0.370) and 0.204 (0.169, 0.244), respectively. When converted to phenotypes, the study population comprised 63.8% rapid acetylators and 36.2% slow acetylators.Conclusions The pattern of NAT2 alleles of Thais is similar to those of many Asian populations, although the frequency of NAT2 * 4 is significantly lower and NAT2 * 7 is higher than that of Oriental populations.