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Sirolimus steady‐state trough concentrations are not affected by bolus methylprednisolone therapy in renal allograft recipients
Author(s) -
Bäckman L.,
Kreis H.,
Morales J. M.,
Wilczek H.,
Taylor R.,
Burke J. T.
Publication year - 2002
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1046/j.1365-2125.2002.01594.x
Subject(s) - methylprednisolone , sirolimus , bolus (digestion) , medicine , urology , trough concentration , trough level , pharmacokinetics , pharmacology , anesthesia , transplantation , tacrolimus
Aims To determine whether bolus doses of methylprednisolone affect the steady‐state trough concentrations of sirolimus. Methods Fourteen renal transplant recipients received concentration‐controlled sirolimus therapy in combination with azathioprine and steroids ( n =8) or mycophenolate mofetil and steroids ( n =6). Bolus doses of methylprednisolone (mean total dose over 1–5 days, 1694 mg; range, 500–3000 mg) were given for the treatment of acute rejection. For each patient, the sirolimus dose (mean, 24.1 mg; range, 3.3–52.5 mg) was the same before and during methylprednisolone therapy. Results Mean sirolimus whole blood trough concentrations before and after treatment with methylprednisolone were 28.8 ng ml −1 (range, 13.9–45.3 ng ml −1 ), and 28.5 ng ml −1 (range, 13.0–47.9 ng ml −1 ), respectively ( P =0.85; 95% confidence interval on the difference −3.3, 4.0 ng ml −1 ). Conclusions Bolus methylprednisolone treatment does not affect steady‐state sirolimus trough concentrations.