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Plasma concentrations of disodium cromoglycate after various inhalation methods in healthy subjects
Author(s) -
Kato Y.,
Muraki K.,
Fujitaka M.,
Sakura N.,
Ueda K.
Publication year - 1999
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1046/j.1365-2125.1999.00979.x
Subject(s) - inhalation , saline , isotonic saline , anesthesia , isotonic , chemistry , disodium cromoglycate , medicine , asthma , plasma concentration , aerosolization , chromatography , pharmacology
AimsTo compare the plasma concentrations of disodium cromoglycate (DSCG) following various inhalation procedures in healthy volunteers.MethodsNine healthy subjects inhaled 2 mg of aerosol, 20 mg of nebuliser solution only, 20 mg of nebuliser solution mixed with isotonic saline, or 20 mg of nebuliser solution mixed with saline and procaterol, a β 2 ‐adenoceptor agonist, on separate occasions 2–3 weeks apart. Plasma concentrations of DSCG were determined by high‐performance liquid chromatography (h.p.l.c.).ResultsThe peak plasma concentrations of DSCG were 1.5±0.7 (range 0.4–2.4) ng ml −1 in the aerosol group, 8.8±6.2 (range 5.3–19.9) ng ml −1 in the nebuliser solution only group, 17.2±16.3 (range 5.0–38.6) ng ml −1 in the nebuliser solution plus isotonic saline group, and 24.5±11.9 (range 10.2–44.9) ng ml −1 in the nebuliser solution plus saline and procaterol group. Thus subjects who used the nebuliser had markedly higher plasma concentrations of DSCG than subjects who used the aerosol inhaler.ConclusionsThese findings may have important implications for the evaluation of inhalation treatment with DSCG for bronchial asthma.